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MSC 2032964A

CAS No. 1124381-43-6

MSC 2032964A( MSC-2032964A | MSC2032964A | MSC 2032964A )

Catalog No. M27999 CAS No. 1124381-43-6

MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

MSDS

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Biological Information

Product Name

MSC 2032964A
Note

Research use only, not for human use.
Brief Description

MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
Description

MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
In Vitro

——
In Vivo

——
Synonyms

MSC-2032964A | MSC2032964A | MSC 2032964A
Pathway

Others
Target

Other Targets
Recptor

Calcium Channel
Research Area

——
Indication

——

Chemical Information

CAS Number

1124381-43-6
Formula Weight

362.316
Molecular Formula

C16H13F3N6O
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Samy MEROUEH, et al. Preparation of pyrazolyl acylpyrazolines for the treatment of pain. WO2020061303A1

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